Kamagaju L, Morandini R, Bizuru E, Nyetera P, Nduwayezu JB, Stévigny C, Ghanem G, Duez P. J Ethnopharmacol. The content of oxymatrine in Kushen root is much higher than that of matrine. We also identified the formation and transport of melanosomes with immunohistochemistry and immunofluorescence analyses. It grows up to 1.5 M. Best used for Cancer. Plamed Oxymatrine is white color, high content, and low cost. Kushen contains: R. Matrine. And it has a few other names, including Sophora Flavescens radix, light yellow sophora root, Flavescent Sophora Root, Root of Light Yellow Sophora, Sophora Flavescens Root, and more. Ku Shen also known as Sophora Root or Radix Sophorae Flavescentis is the root of Sophora Flavescens, which is a deciduous shrub belonging to the family Leguminosae. In this study, we found that the water extract of roots of Sophora flavescens extended the axons of mouse cortical neurons, even on a CSPG-coated surface. Oxymatrine has been proven to be an effective antibacterial agent that promotes hair growth and circulation. Tyrosinase modulation by five Rwandese herbal medicines traditionally used for skin treatment. Likewise, it has different medicinal properties and health benefits. Plamed oxymatrine is medical grade, high safety, good water solubility, high purity, and white color. Oxymatrine can exert its anti-inflammatory effect through changes of immune cells, cytokines and other inflammatory regulatory factors. Sophora flavescens or Ku Shen, which in Chinese means “bitter root,” is an herb used in Traditional medicine to treat a wide variety of symptoms, with purported effects on the liver, intestinal tract, and skin. In addition, a clinical trial of a cream containing 0.05% S. flavescens extract on human skin showed it had a significant effect on skin whitening by mechanical and visual evaluation (1.14-fold). Sophora Flavescens Root Extract Oxymatrine has been a focal point of Chinese medical research into the treatment of cancer, viral hepatitis, viral myocarditis and skin diseases such as psoriasis and excema over the past 15 years. Sophorae Root Extract/organic Anti-cancer Radix Sophorae Flavescentis Kuh-seng Extract for Pharmaceutical Use. After topical application of Sophora flavescens extract onto the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen was induced. It is extracted from the plant “Sophora Flavescens Ait”, which medicinally mainly refers to the dried root of Sophora Flavescens Ait. not reported and skin conditioning. In search of natural extracts for hair growth, we found that the extract of dried root of Sophora flavescens has outstanding hair growth promoting effect. Use of an extract from Sophora flavescens or Sophora subprostrata for the preparation of a medicament for the prophylaxis and treatment of pathological conditions caused by a deficiency of oestrogens or by a dysregulation of sex hormone metabolism, particularly oestrogen metabolism. Bitter sophora root, as a medicinal plant, has the functions of clearing heat, diuresis, insecticide, dispelling dampness and so on.It also has the functions of anti-virus, anti-tumor and anti-allergy. It grows in a tropical climate. This site needs JavaScript to work properly. Oxymatrine and matrine are the main components of sophora flavescens alkaloids. 2. It has a good treatment of eczema and dermatitis, and can alleviate skin itching caused by inflammation. Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers. 2011 Jun;33(3):210-21. doi: 10.1111/j.1468-2494.2010.00616.x. Clinical medicine. Draco Natural Products Inc. Test Data Available. It has been used to treat a variety of conditions, such as … 6 Cosmetics Ingredients containing SOPHORA FLAVESCENS ROOT EXTRACT. And it has a few other names, including Sophora Flavescens radix, light yellow sophora root, Flavescent Sophora Root, Root of Light Yellow Sophora, Sophora Flavescens Root, and more. The anti-inflammatory mechanism of oxymatrine is due to the stabilization of erythrocyte membrane. Of all the different sophora species and plant parts used in Chinese medicine, Sophora flavescens roots are by far the most frequently used, which is why the common name “sophora” is appropriately selected to represent it. Oxymatrine: Sophora Angustifolia Extract for Skin Care. Website: www.plamed.cn, American Branch:Plamed Corp 1. Results: They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation. Which is a plant in the family Leguminosae? Wound Healing and the Use of Medicinal Plants. Int J Cosmet Sci. Skin conditioning; COSING REF No: 83737 Chem/IUPAC Name: Sophora Flavescens Root Extract is the extract of the roots of Sophora flavescens, Fabaceae 6. Oxymatrine has been widely used in cosmetics, such as Shiseido Elixir Superieur Lifting Moisture Lotion II, Cle De Peau Beaute Gentle Cleansing Foam and other skin care products. However, oxymatrine has an oxygen structure in its structure, which can change molecule polarity. Materials and methods: Both of them can be transformed in vitro and in vivo; wherein oxymatrine’s nitrogen atom is combined with oxygen by a coordination bond. Materials and methods Materials The ethanol extracts of the roots of S. flavescens and Whatsapp: +86 180 6683 3765 So oxymatrine has some skin-care effect: anti-acne and anti-inflammatory. Oxymatrine has broad-spectrum antibacterial property. In addition, a clinical trial of a cream containing 0.05% S. flavescens extract on human skin showed it had a significant effect on skin whitening by mechanical and visual evaluation (1.14-fold). Sophora Angustifolia Root Extract is an extract of the roots of Sophora angustifolia. Sophora flavescens is a deciduous shrub related to peas. Oxymatrine is water-soluble; it is clear and transparent in aqueous solution. SOPHORA. Cancer Treatment : Useful in treating Cancer of Reproductive Organs, Respiratory Tract and Liver Cancer. Nature’s Health 100% Pure Ku Shen Veggie Capsules are a suitable and invigorating way to receive the all-natural support of Ku Shen. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. NLM This study provides important clues toward understanding the effects of S. flavescens extract on the formation and transport of melanosomes. We investigated the changes in the mRNA levels of genes associated with the formation and transport of melanosomes. Clipboard, Search History, and several other advanced features are temporarily unavailable. Buy amazing sophora flavescens extract on Alibaba.com at irresistible offers and enhance your well-being. The root known as “Ku Shen” which means “bitter root” in Chinese, has been used in Traditional Medicine for two thousand years to treat a variety of conditions, including diarrhea, jaundice, skin rashes, and to kill parasites. Sophora Angustifolia Root Extract Sophora angustifolia is a small shrub in the pea family (Fabaceae). This plant often grows on hillsides, grass … Discussion and conclusion: 2017 Jul 1;25(4):390-395. doi: 10.4062/biomolther.2016.156.  |  Sophora flavescens has shown anticancer effects in lab studies, but has not been studied for cancer prevention or treatment in humans. Skype: plamed06 Alibaba.com offers 274 sophora flavescens liquid products. It not only can be used as a topical skin conditioning agent in cosmetics, but also can be injected to treat skin diseases. It has a medicinal history of more than 2,000 years. Diuresis. Sophora Tincture Alcohol Extract, Organic Ku Shen, Sophora (Sophora Flavescens) Dried Root Tincture Supplement (4 FL OZ) 5.0 out of 5 stars 2 $29.97 $ 29 . Therefore, in this study, we investigated the whitening effect of a natural product, S. flavescens extract, as a new whitening agent for cosmetics. After the digging, for better medicinal quality it should remove the head and small fibrous root, wash clean, and dry immediately or dry after slicing when it is still fresh. Whitening agents act at various levels of melanin production in the skin. Matrine and oxymatrine have similar physiological activities, but there are still differences. Add:1932 S Lynx Place, Ontario, CA, 91761, Soluble in water, methanol, chloroform, benzene; insoluble in ether, Soluble in water, benzene, chloroform, methanol, ethanol; slightly soluble in petroleum ether. Sophora (Ku Shen) Root . Under certain condition, nitrogen-oxygen bond is cleaved and converted into matrine. Oxymatrine, also known as matrine oxide, matrine N-oxide, matrine 1-oxide, is a natural active ingredient extracted from dried root of Sophora flavescens. Oxymatrine, as sophora angustifolia root extract, provides rich nutrition for hair and scalp. And it can exist in plants in a relatively stable natural form. 2013 Apr 19;146(3):824-34. doi: 10.1016/j.jep.2013.02.010. Oxymatrine. 2. So it can be added as water phase component into cosmetics, and can be added to various types of cosmetics such as lotion, toner, essence, and cream. Ku Shen, also known as Sophora Flavescens, can be used a supplement of a diet that is intended to contribute to the maintenance of healthy skin. Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. Oxymatrine has an effect of improving skin wrinkles. 6 Applications of Matrine. Epub 2011 Jan 25. Its biological activity is higher than that of matrine. And it is usually used raw. Tel: 0086-29-88211806 2019 Sep 22;2019:2684108. doi: 10.1155/2019/2684108. Plamed Oxymatrine is white color, high content, and low cost. In search of natural extracts for hair growth, we found that the extract of dried root of Sophora flavescens has outstanding hair growth promoting effect.After topical application of Sophora flavescens extract onto the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen was induced. Sophora extract has been used for acne to control bacteria and reduce 5 alpha reductase activity, which synthesizes DHT. Context: by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon. The root known as “Ku Shen” which means “bitter root” in Chinese, has a long history of use in traditional medicine. Sophora flavescens Ait. Oxymatrine has lower cytotoxicity than retinol; and it exhibits an inhibitory effect on collagenase activity and a promotion of collagen biosynthesis. Also Oxymatrine acts as an anti-allergic agent; it inhibits physical pain, chemical irritating pain, and neuropathic pain, and relieves skin pain caused by inflammatory allergies. …  |  Oxymatrine is a botanical cosmetic ingredient that has anti-acne and anti-inflammatory property. Combined with other Chinese herb extracts, it has function of anti-inflammatory, blood circulation and cell regeneration. Welcome to click Oxymatrine for more information. Plamed aims to develop natural cosmetics raw materials. Welcome to click, White Willow Bark (Salix Alba ) Extract for Skin Care, Portulaca Oleracea Extract – Protective Umbrella for Sensitive Skin, Plamed participated in the 2017 Vitafoods Exhibition. skin-whitening effect of S. flavescens extract was analyzed on human skin. Sophora Flavescens Extract, the shrubby sophora,is a species of plant in the genus Sophora of the family Fabaceae.This genus contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceania, and the Pacific islands. Also Known As - sophora flavescens radix, lightyellow sophora root, Flavescent Sophora Root, Root of Light Yellow Sophora, Sophora Flavescens Root Overview - Though literally translated as bitter ginseng in English, Ku Shen has nothing to do with ginseng at all. And now it is consumed in various forms, like sophora flavescens supplement, extract… Oxymatrine is commonly known as SOPHORA ANGUSTIFOLIA ROOT EXTRACT in cosmetic formulation. Although axonal extension to reconstruct spinal tracts should be effective for restoring function after spinal cord injury (SCI), chondroitin sulfate proteoglycan (CSPG) levels increase at spinal cord lesion sites, and inhibit axonal regrowth. Lee HJ, Lee SY, Jang D, Chung SY, Shim I. Biomol Ther (Seoul). The hunt for natural skin whitening agents. Functions. Search by keywords . 2015 Apr;78(1):67-75. doi: 10.1016/j.jdermsci.2015.01.014. About 0% of these are Essential Oil, 1% are Skin Care Serum. Sophora root mainly contains alkaloids, flavonoids, quinones, and triterpenoid saponins. Discussion and conclusion: This study provides important clues toward understanding the effects of S. flavescens extract on the formation and transport of melanosomes. Evid Based Complement Alternat Med. Mobile: +86 180 6683 3765 Sophora Flavescens is a shrub. This genus contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceania, and the Pacific islands.About fifteen of these species have a long history of use in traditional Chinese medicines. COVID-19 is an emerging, rapidly evolving situation. The proven health benefits of sophora flavescens extract will leave you with a smile. Anti-melanogenic effects of Aster spathulifolius extract in UVB-exposed C57BL/6J mice and B16F10 melanoma cells through the regulation of MAPK/ERK and AKT/GSK3β signalling. By inhibiting tyrosinase, oxymatrine can reduce pigmentation caused by skin aging and ultraviolet radiation. Moreover, oxymatrine is also easily soluble in organic solvents including methanol, chloroform and benzene. EWG’s Skin Deep® database gives you practical solutions to protect yourself and your family from everyday exposures to chemicals in personal care products. Each bottle contains 60 vegetarian capsules at 480mg. (Leguminosae) has been proposed as a new whitening agent for cosmetics, because it has a strong ability to inhibit tyrosinase, a key enzyme in the formation of melanin. (TCM). NIH Email: sale@plamed.cn We conducted a study to determine whether ethanol extract of the roots of S. flavescens has the potential for use as a whitening cosmetic agent by investigating its underlying mechanisms of action. SOPHORA ANGUSTIFOLIA EXTRACT, SOPHORA ANGUSTIFOLIA ROOT EXTRACT, and SOPHORA FLAVESCENS ROOT EXTRACT. Synonyms. Epub 2015 Feb 4. Sophora Root Extract sophora angustifolia root extract 【Botanic Name】Sophora flavescens 【Use Part】Root 【Specifications】98% Oxymatrine. It may also inhibit the 5-Alpha Reductase enzyme and PDE5 potently, promoting hair growth and erectogenesis. Oxymatrine, also known as matrine oxide, matrine N-oxide, matrine 1-oxide, is a natural active ingredient extracted from dried root of Sophora flavescens. As alkaloids, oxymatrine and matrine have same pharmacological effect. To elucidate the mechanism of action of S. flavescens extract, we used DNA microarray technology.  |  2016 Apr;68(4):503-13. doi: 10.1111/jphp.12524. Finally, the skin-whitening effect in vivo of S. flavescens extract was analyzed on human skin. Wechat: 18066833765, Add: D302 Gazelle Valley, Pioneering R&D Park, NO.69 Jinye Road, High-tech Zone, Xi’an ,China HHS And it has strong immunomodulatory effect. Sophoraflavanone G. Sophoflavescenol. 1. This post is a little more general, as I have done extensive posts on some specific alkaloids of Kushen (see below). Sophora Flavescens, 8% extract. Please enable it to take advantage of the complete set of features! Evid Based Complement Alternat Med. Sophora flavescens, the shrubby sophora, is a species of plant in the genus Sophora of the family Fabaceae. We found that S. flavescens extract strongly inhibited tyrosinase activity (IC50, 10.4 μg/mL). Plamed aims to develop natural cosmetics raw materials. Differences Between Oxymatrine and Matrine. A wide variety of sophora flavescens liquid options are available to you, Sophora flavescens Sophora Flavescens (Ku Shen) is a medicinal herb from China that appears to possess mostly anti-cancer properties. Oxymatrine is widely used for anti-acne and anti-inflammatory in cosmetics. Tel: 0086-29-88215350 Epub 2013 Feb 22. Allomatrine Oxymatrine is commonly known as SOPHORA ANGUSTIFOLIA ROOT EXTRACT in cosmetic formulation. Int J Mol Sci. LPS: Lipopolysaccharides; COX: Cyclooxygenase. Sophora angustifolia root extract is one of the three major plant soothing agents for skin care (the other two are licorice extract and astragalus extract). Usui K, Ikeda T, Horibe Y, Nakao M, Hoshino T, Mizushima T. J Dermatol Sci. Oxymatrine inhibits histamine release from mast cells induced by IgE (immunoglobulin E) and antigens. January 16, 2019Cosmetic ingredients. Sophora Flavescentis Root Extract is commonly used for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). E-mail: sales@plamed.cn Oxymatrine has an action of inhibiting tyrosinase, and inhibits melanin production. Sophora flavescens (Ku Shen, Kushen, Ku-Shen, Kujin, shrubby sophora) is a commonly used root in Traditional Chinese Medicine. It is produced all over China and harvested during spring and autumn. China Sophora Flavescens Extract Insecticide Pesticide Matrine, Find details about China Matrine, Oxymatrine from Sophora Flavescens Extract Insecticide Pesticide Matrine - … From these results, we suggest that naturally occurring S. flavescens extract might be useful as a new whitening agent in cosmetics. The melanogenesis and mechanisms of skin-lightening agents--existing and new approaches. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. HPLC-based activity profiling of extracts the traditional Chinese herbal drug Kushen (Sophora flavescens root) led to the identification of the 8-lavandulyl flavonoids, kushenol I, sophoraflavanone G, and (−)-kurarinone, and the related chalcone kuraridine as GABA A receptor modulators (Yang, Baburin, Plitzko, Hering, & Hamburger, 2011). It has a skin-whitening effect. Epub 2016 Mar 19. What is Sophora Flavescens Extract Matrine Oxymatrine? Objective: It is an evergreen. In TCM : Sophora Flavescens Root : Ku Shen Jian Meridians associated : Heart, Urinary Bladder, Liver, Small Intestine and Large Intestine.